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J Neuroimmunol. 2004 Feb;147(1-2):141-4.

Interleukin-6 in the aging brain.

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  • 1Laboratory of Integrative Biology, Department of Animal Sciences, University of Illinois at Urbana-Champaign, 61801, USA.

Abstract

Astrocytes, microglia, and neurons express the cytokine interleukin-6 (IL-6), which in the brain has been suggested to reduce food intake, inhibit memory and learning, cause neurodegeneration, and exacerbate sickness behavior induced by other cytokines. Recent evidence indicates IL-6 levels are increased in brain of healthy aged animals, thus it may play a role in the neurophysiological manifestations of old age. The purpose of this brief report is to discuss the new evidence that suggests an age-related increase in brain IL-6 and the impact this inflammatory cytokine may have on "successful" aging.

PMID:
14741447
[PubMed - indexed for MEDLINE]
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