Send to:

Choose Destination
See comment in PubMed Commons below
Bioorg Med Chem Lett. 2004 Feb 9;14(3):667-71.

Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.

Author information

  • 1Department of Biochemistry, Drexel University College of Medicine, Philadelphia, PA 19102, USA.


The nonsteroidal anti-inflammatory drugs flurbiprofen and ibuprofen were modified in an attempt to alter the kinetics of inhibitor binding by COX-1. Contrary to prior predictions, a halogen substituent is not sufficient to confer slow tight-binding behavior. Conversion of the carboxylate moiety of flurbiprofen to an ester or amide abolishes slow tight-binding behavior, regardless of halogenation state.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk