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    Science. 2004 Feb 27;303(5662):1371-4. Epub 2004 Jan 22.

    Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.

    Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM.

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    Department of Molecular Oncology, Genentech, Inc., South San Francisco, CA 94080, USA.

    Abstract

    Arabidopsis thaliana De-etiolated-1 (AtDET1) is a highly conserved protein, with orthologs in vertebrate and invertebrate organisms. AtDET1 negatively regulates photomorphogenesis, but its biochemical mechanism and function in other species are unknown. We report that human DET1 (hDET1) promotes ubiquitination and degradation of the proto-oncogenic transcription factor c-Jun by assembling a multisubunit ubiquitin ligase containing DNA Damage Binding Protein-1 (DDB1), cullin 4A (CUL4A), Regulator of Cullins-1 (ROC1), and constitutively photomorphogenic-1. Ablation of any subunit by RNA interference stabilized c-Jun and increased c-Jun-activated transcription. These findings characterize a c-Jun ubiquitin ligase and define a specific function for hDET1 in mammalian cells.

    PMID:
    14739464
    [PubMed - indexed for MEDLINE]

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