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J Nat Prod. 2004 Jan;67(1):26-30.

New geranyl stilbenes from Dalea purpurea with in vitro opioid receptor affinity.

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  • 1Department of Chemistry and Biochemistry, The University of Tulsa, Tulsa, OK 74101, USA.


Three new geranyl stilbenes, pawhuskins A, B, and C (1, 2, and 3), were isolated from organic extracts of Dalea purpurea. The structures of the three compounds were determined by NMR and HRMS methods. The activities of these compounds, along with that of the known compound petalostemumol (4), were evaluated in an opioid receptor assay in vitro. Pawhuskin A (1) exhibited the strongest activity of the four compounds with a K(i) value of 0.29 +/- 0.11 microM.

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