Department of Dermatology and Pathology, University of Virginia Health System, Charlottesville 22908-0718, USA. jce2n@virginia.edu
BACKGROUND: Granular parakeratosis is a hyperkeratotic eruption of unknown etiology that occurs in the axilla and other intertriginous areas. The histologic features are unique for the retention of keratohyalin granules in the stratum corneum. OBJECTIVE: The aim of the article is to review the clinical manifestations and treatment of granular parakeratosis. Methods: A case report and literature review are presented. RESULTS: Twenty-six cases of granular parakeratosis now have been reported and reviewed. CONCLUSION: Granular parakeratosis occurs predominantly in middle age women and most frequently in the axilla. A number of treatments have been applied to the 26 cases reported to date, without consistent responses. No evidence-based therapy can be suggested at present.