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Infection. 2003 Dec;31(6):392-7.

Meningococcal disease in catalonia 1 year after mass vaccination campaign with meningococcal group C polysaccharide vaccine.

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  • 1General Directorate of Public Health, Generalitat de Catalunya, Pavello Ave Maria, Trav. De les Corts, 131-159, E-08028 Barcelona, Spain.

Abstract

BACKGROUND:

The aim of this study was to investigate the clinical and epidemiological characteristics of meningococcal disease in Catalonia (Spain) after vaccination with the polysaccharide vaccine.

PATIENTS AND METHODS:

Cases were collected by the Statutory Diseases Reporting System.

RESULTS:

176 cases were reported, an overall incidence of 2.9/100,000 persons/year. 60% of cases occurred during winter and spring. The case fatality rate was 6.3%. The highest age incidence was in children under 2 years of age (48/100,000 persons/year). Comparison of the cases detected by the Statutory Diseases Reporting System with those obtained by the Microbiological Reporting System shows that meningococcal disease surveillance in Catalonia was relatively complete (95.7%), with a positive predictive value of 66.3%. 115 cases (65%) were culture-confirmed with a rate of 1.9/100,000 persons/year. 86 (75%) cases were due to Neisseria meningitidis serogroup B and 21 to serogroup C (18%).

CONCLUSION:

Although infections due to serogroup C have decreased after mass vaccination with the polysaccharide vaccine, it is likely that the number of infections will decrease further with the conjugate meningococcal group C vaccine.

PMID:
14735381
[PubMed - indexed for MEDLINE]
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