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Trends Cell Biol. 1995 Aug;5(8):297-301.

Chromosomes take the lead in spindle assembly.

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  • 1European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.


Several kinesin-like motor proteins have recently been found associated with chromosome arms. They seem to be involved in the so-called 'polar ejection forces' that contribute to the congression of chromosomes on the metaphase plate, and at least one of them is essential for the maintenance of spindle bipolarity. The discovery of these molecules changes our view of the mechanism of spindle assembly and chromosome movement.

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