Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 1995 Nov;5(11):424-8.

Macropinocytosis.

Author information

  • 1Dept of Cell Biology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

Abstract

Macropinocytosis is a form of endocytosis that accompanies cell surface ruffling. It is distinct in many ways from the better characterized micropinocytosis, which includes clathrin-coated vesicle endocytosis and small uncoated vesicles. Because macropinosomes are relatively large, they provide an efficient route for non-selective endocytosis of solute macromolecules. This route may facilitate MHC-class-II-restricted antigen presentation by dendritic cells. Because the ruffling that leads to macropinocytosis is regulated, it has been exploited by some pathogenic bacteria as a novel route for entry into cells.

PMID:
14732047
[PubMed]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk