Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 1995 May;5(5):183-6.

Biogenesis of phagolysosomes: the 'kiss and run' hypothesis.

Author information

  • Département d'anatomie, Faculté de médecine, Université de Montréal, Centre Ville, Canada.


Particles such as microorganisms that are taken up by the cell into phagosomes are usually ultimately degraded in phagolysosomes. However, despite its importance, phagolysosome biogenesis is poorly understood. This article presents a model for phagosome maturation into phagolysosomes that involves multiple transient fusion-fission interactions of phagosomes with endocytic organelles via a fusion-pore-like structure. This dynamic process may be modulated by the sequential appearance and disappearance of key phagosome proteins.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk