Int J Neuropsychopharmacol. 2004 Mar;7(1):65-70. Epub 2004 Jan 20.

Acute augmentation of serotonin suppresses cardiovascular responses to emotional valence.

Source

Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria VIC 3122, Australia.

Abstract

A key component in visceral reactivity to emotional states is heart rate (HR), however little is known about how HR response to emotional stimuli is modulated by neurochemicals. The present study investigated the way in which acute enhancement of serotonin (5-HT) function with a selective serotonin reuptake inhibitor (SSRI) modulates the HR associated with differently valent images (pleasant, neutral, unpleasant). Sixteen healthy participants viewed 75 images whilst HR was recorded. Participants were tested under two single-dose treatment conditions: placebo and citalopram (20 mg). Our findings suggest: (1) HR is able to differentiate differently valent images during placebo treatment and, (2) administration of citalopram suppresses the differences in HR between differently valent images. These results suggest that 5-HT may modulate the cardiovascular HR response to visual emotional stimuli and indicate that 5-HT may have a protective effect on the cardiovascular responses to emotional stimuli.

PMID:: 14731312; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

CITALOPRAM HYDROBROMIDE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Augmentation of serotonin enhances pleasant and suppresses unpleasant cortical electrophysiological responses to visual emotional stimuli in humans. [Neuroimage. 2004]
Augmentation of serotonin enhances pleasant and suppresses unpleasant cortical electrophysiological responses to visual emotional stimuli in humans.
Kemp AH, Gray MA, Silberstein RB, Armstrong SM, Nathan PJ. Neuroimage. 2004 Jul; 22(3):1084-96.
Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: an event-related potential (ERP) investigation. [J Psychopharmacol. 2010]
Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: an event-related potential (ERP) investigation.
Labuschagne I, Croft RJ, Phan KL, Nathan PJ. J Psychopharmacol. 2010 Aug; 24(8):1153-64. Epub 2008 Oct 2.
Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study. [Psychopharmacology (Berl). 2009]
Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study.
Kerestes R, Labuschagne I, Croft RJ, O'Neill BV, Bhagwagar Z, Phan KL, Nathan PJ. Psychopharmacology (Berl). 2009 Mar; 202(4):621-34. Epub 2008 Sep 30.
Direct evidence that acutely enhancing serotonin with the selective serotonin reuptake inhibitor citalopram modulates the loudness dependence of the auditory evoked potential (LDAEP) marker of central serotonin function. [Hum Psychopharmacol. 2006]
Direct evidence that acutely enhancing serotonin with the selective serotonin reuptake inhibitor citalopram modulates the loudness dependence of the auditory evoked potential (LDAEP) marker of central serotonin function.
Nathan PJ, Segrave R, Phan KL, O'Neill B, Croft RJ. Hum Psychopharmacol. 2006 Jan; 21(1):47-52.
Review [Escitalopram: a selective inhibitor and allosteric modulator of the serotonin transporter]. [Encephale. 2007]
Review [Escitalopram: a selective inhibitor and allosteric modulator of the serotonin transporter].
Mnie-Filali O, El Mansari M, Scarna H, Zimmer L, Sánchez C, Haddjeri N. Encephale. 2007 Dec; 33(6):965-72. Epub 2007 Dec 11.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Acute augmentation of serotonin suppresses cardiovascular responses to emotional...
Acute augmentation of serotonin suppresses cardiovascular responses to emotional valence.
Int J Neuropsychopharmacol. 2004 Mar ;7(1):65-70. Epub 2004 Jan 20 .

PubMed
Cross-species hybridization of a Borrelia burgdorferi DNA array reveals infectio...
Cross-species hybridization of a Borrelia burgdorferi DNA array reveals infection- and culture-associated genes of the unsequenced genome of the relapsing fever agent Borrelia hermsii.
Mol Microbiol. 2004 Feb ;51(3):729-48.

PubMed
DNA sequence, polymorphism, and mapping of luteinizing hormone receptor fragment...
DNA sequence, polymorphism, and mapping of luteinizing hormone receptor fragment (LHCGR) gene in Great Dane dogs.
Anim Genet. 2004 Feb ;35(1):74-5.

PubMed
Suicide after discharge from psychiatric inpatient care: a case-control study in...
Suicide after discharge from psychiatric inpatient care: a case-control study in Hong Kong.
Aust N Z J Psychiatry. 2004 Jan-Feb ;38(1-2):65-72.

PubMed
The First-Time Fathers Study: a prospective study of the mental health and wellb...
The First-Time Fathers Study: a prospective study of the mental health and wellbeing of men during the transition to parenthood.
Aust N Z J Psychiatry. 2004 Jan-Feb ;38(1-2):56-64.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: