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J Bacteriol. 2004 Feb;186(3):889-93.

Expression of Vibrio vulnificus capsular polysaccharide inhibits biofilm formation.

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  • 1Aquatic Food Products Laboratory, Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA.


Vibrio vulnificus is a human pathogen that produces lethal septicemia in susceptible persons, and the primary virulence factor for this organism is capsular polysaccharide (CPS). The role of the capsule in V. vulnificus biofilms was examined under a variety of conditions, by using either defined CPS mutants or spontaneous CPS expression phase variants derived from multiple strains. CPS expression was shown to inhibit attachment and biofilm formation, which contrasted with other studies describing polysaccharides as integral to biofilms in related species.

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