Trends Cell Biol. 2004 Jan;14(1):1-5.

The molecular mystery of neuronal migration: FAK and Cdk5.

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MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, London SE1 1UL, UK. margareta.nikolic@kcl.ac.uk

Abstract

The basic building blocks of a cell are its cytoskeletal proteins, the orderly but dynamic organization of which is essential. How signalling molecules regulate the cytoskeleton in the developing nervous system is still largely unknown. A recent breakthrough sheds light on a pathway involving Cdk5 (cyclin-dependent kinase 5) and FAK (focal adhesion kinase), demonstrating their role in regulating microtubule structure and thus nuclear positioning in radially migrating cortical neurones.

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