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Clin Infect Dis. 2004 Feb 1;38(3):430-2. Epub 2004 Jan 9.

Analyzing sleep abnormalities in HIV-infected patients treated with Efavirenz.

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  • 1Service of Infectious Diseases, Hospital Carlos III, Instituto de Salud Carlos III, Madrid, Spain.

Abstract

Ambulatory electroencephalogram monitoring was performed for 18 HIV-infected subjects treated with efavirenz with and without insomnia and for 13 healthy control subjects. All patients receiving efavirenz had longer sleep latencies and shorter duration of deep sleep, although poor sleepers also showed reduced sleep efficiency and shorter duration of rapid eye movement sleep. Efavirenz plasma levels were higher in patients with insomnia and/or reduced sleep efficiency.

PMID:
14727217
[PubMed - indexed for MEDLINE]
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