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Clin Hemorheol Microcirc. 2003;29(3-4):157-65.

Microcirculation: target therapy in cardiovascular diseases - a clinical perspective.

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  • 1Department of Medicine, Philippine General Hospital-College of Medicine, University of the Philippines, Manila, Philippines.


Microcirculation conduit, distribution, exchange and reception vessels usually retain a demand-dependent vascular-tissue match as well as a nutrient friendly capillary-matrix tissue match. Various stimuli can initiate a vascular-capillary matrix-tissue mismatch. Counter-regulatory mechanisms result in hyperplasia or apoptosis. Microvascular disease (MVD) as a consequence or outcome of supply-demand mismatch has clinical therapeutic and prognostic implications in the hypertensive syndrome and coronary artery disease (CAD) cases. Recognition of the role of apoptosis and MVD may initiate a paradigm shift in clinical practice. Digitalis and other anti-hypertensive agents have anti-apoptotic action and MVD blunting effects that can control LVH development to reduce congestive heart failure (CHF) progression.

[PubMed - indexed for MEDLINE]
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