Clin Exp Dermatol. 2004 Jan;29(1):35-6.

Warfarin skin necrosis associated with protein S deficiency and a mutation in the methylenetetrahydrofolate reductase gene.

Byrne JS, Abdul Razak AR, Patchett S, Murphy GM.

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Department of Dermatology, Beaumont Hospital & Private Clinic, Beaumont, Dublin 9, Ireland.

Abstract

The use of warfarin is rarely complicated by skin necrosis. We describe a 50-year-old woman who presented with a left leg deep venous thrombosis and subsequent pulmonary embolism. She was initially anticoagulated with low-molecular weight heparin and subsequently warfarin. Within 4 days abdominal skin necrosis developed. Investigations revealed the presence of protein S deficiency and in addition, a mutation in the methylenetetrahydrofolate reductase gene (MTHFR). We present, to our best knowledge, the first case of warfarin skin necrosis associated with a methylenetetrahydrofolate reductase mutation.

PMID:: 14723717; [PubMed - indexed for MEDLINE]

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