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    Biotechnol Appl Biochem. 2004 Oct;40(Pt 2):181-5.

    Generation of polyclonal antibodies against multiple proteins in a single rabbit and subsequent isolation of the specific immunoglobulins as a tool for proteomics research.

    Jacquot JP, Rouhier N, Navrot N, Decottignies JP.

    UMR INRA UHP 1136, Interaction Arbres Microorganismes, Université Henri Poincaré, Faculté des Sciences, BP 239, 54506 Vandoeuvre Cédex, France. j2p@scbiol.uhp-nancy.fr

    A single rabbit has been immunized with a mixture of six different proteins: green fluorescent protein, ferredoxin:NADP oxidoreductase, NADPH:thioredoxin reductase, thioredoxin f, fructose bisphosphatase and cyclophilin. Individual IgGs were re-purified from the serum through specific interaction on small columns generated by grafting the antigen on a CNBr-Sepharose matrix. The specificity of the isolated IgG was checked by Western-blot analysis. Purified and specific IgG fractions were obtained with all antigens except thioredoxin f.

    PMID: 14723601 [PubMed - indexed for MEDLINE]

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