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J Clin Invest. 2004 Jan;113(2):182-4.

Bateman domains and adenosine derivatives form a binding contract.

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  • St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. kemp@ariel.unimelb.edu.au


Conserved pairs of CBS sequence motifs (named after cystathionine beta-synthase) found in a wide variety of proteins associate to form Bateman domains. A new study establishes that Bateman domains bind adenosyl compounds and regulate IMP dehydrogenase, CBS, chloride channels, and AMP-activated protein kinase. This discovery reveals how mutations in CBS sequences in these proteins cause hereditary diseases and provides a rich vista of conceptual opportunities for therapies in energy metabolism, obesity, diabetes, cancer, antivirals, and immunosuppression.

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