To study the clinical effects of Da Ding Feng Zhu ([symbol: see text]) Decoction on liver fibrosis. 56 patients with liver fibrosis due to chronic hepatitis B were randomly divided into a treatment group (30 cases treated with Da Ding Feng Zhu Decoction) and a control group (26 cases treated with colchicine). The serum levels of hyaluronic acid (HA), procollagen III (PC-III), IV collagen (IV-C) and Laminin (LN) of the patients were determined, compared and analyzed before treatment and after 3-month treatment in the two groups. The results showed that in the treatment group, the levels of HA, PC-III, IV-C and LN after 3-month treatment were significantly lowered as compared to that before treatment (P < 0.01). In the control group, only the HA level was obviously lowered (P < 0.05). There was an significant difference (P < 0.05) in PC-III and IV-C and a very significant difference (P < 0.01) in HA after treatment between the two groups. It is therefore concluded that Da Ding Feng Zhu Decoction can lower serum indexes of liver fibrosis.