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Chang Gung Med J. 2003 Oct;26(10):737-44.

Amniotic membrane grafts following excision of corneal and conjunctival intraepithelial neoplasia.

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  • 1Department of Ophthalmology, Chang Gung Memorial Hospital, Taipei.

Abstract

BACKGROUND:

We evaluated the efficiency of amniotic membrane grafts (AMGs) for reconstructing the conjunctival surface following excision of corneal and conjunctival intraepithelial neoplasia (CIN).

METHODS:

This was a retrospective, noncomparative, interventional study. Five eyes in 5 patients were treated between April 1996 and September 2002 with the same procedure to apply amniotic membrane grafts after excising CIN. According to a standard protocol, the amniotic membrane was harvested and processed under sterile conditions. The amniotic membrane graft was applied over the excised bare scleral area and anchored with 10-0 nylon interrupted sutures. Patient data and clinical photographs were reviewed and analyzed.

RESULTS:

The mean follow-up period was 27 (range, 6-69) months. Ocular surface healing was rapid and complete in all cases. No recurrence was found.

CONCLUSION:

Amniotic membrane graft is an effective and safe alternative adjunctive treatment for primary CIN. Further studies with longer follow-up are recommended to evaluate the risk of recurrence and other adverse effects.

PMID:
14717208
[PubMed - indexed for MEDLINE]
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