Acta Psychiatr Scand. 1992 Dec;86(6):478-83.

Evaluation of the effects of total sleep deprivation on cerebral blood flow using single photon emission computerized tomography.

Volk S, Kaendler SH, Weber R, Georgi K, Maul F, Hertel A, Pflug B, Hör G.

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Department of Psychiatry II, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

Abstract

HMPAO-single photon emission computerized tomography (SPECT) is a useful technique in studying cerebral blood flow (CBF). This method is suitable to evaluate the differences of CBF with reference to total sleep deprivation (TSD) within 24 h because of the short half-life of the radiopharmaceutical compound. In the present study, CBF before and after TSD was analysed in patients suffering from major depression. The morning before and after TSD, Tc-HMPAO-SPECT was performed in 20 patients. Hamilton Rating Scale for Depression scores and subjective ratings were obtained daily. Eleven patients responded to TSD; 9 were nonresponders. The main finding was a significant left temporal and mainly right parietal increase of CBF, which was observed in the responders only. CBF values and the severity of depression correlated inversely.

PMID:: 1471542; [PubMed - indexed for MEDLINE]

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Evaluation of the effects of total sleep deprivation on cerebral blood flow using single photon emission computerized tomography.

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