Acta Psychiatr Scand. 1992 Dec;86(6):455-62.

Study of chronic schizophrenics using 31P magnetic resonance chemical shift imaging.

Fujimoto T, Nakano T, Takano T, Hokazono Y, Asakura T, Tsuji T.

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Department of Psychiatry, South Japan Health Science Centre, Fujimoto Hospital.

Abstract

Phosphorus-31 chemical shift imaging showed regional abnormalities of in vivo 31P NMR spectra in the brains of chronic schizophrenic patients. In the left temporal region, the level of % phosphodiesters (PDE) was increased and the level of % gamma alpha beta-ATP (obtained by summation of gamma-ATP, alpha-ATP, and beta-ATP) was decreased. In the basal ganglia, the levels of % PDE were decreased and the level of % phosphomonoesters was increased. The levels of % gamma alpha beta-ATP were increased in the right basal ganglia. The level of % phosphocreatine was decreased in the frontoparietal region. These findings may represent different patterns of dysfunction of membrane phospholipid bilayers and high-energy phosphate metabolism in the specific cerebral regions.

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