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Curr Biol. 2004 Jan 6;14(1):R27-9.

Centrosomes: Sfi1p and centrin unravel a structural riddle.

Author information

  • Tumor Biology Program, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA. salisbury@mayo.edu

Abstract

The discovery of Sfi1p as a novel binding partner for the Ca2+-binding protein centrin has provided new insight into the dynamic behavior of centrosomes. Sfi1 binds to multiple centrin molecules along a series of internal repeats, and the complex forms Ca2+-sensitive contractile fibers that function to reorient centrioles and alter centrosome structure.

PMID:
14711432
[PubMed - indexed for MEDLINE]
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