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Genome Biol. 2003;5(1):201. Epub 2003 Dec 23.

Computational prediction of transcription-factor binding site locations.

Author information

  • Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. mlbulyk@rascal.med.harvard.edu

Abstract

Identifying genomic locations of transcription-factor binding sites, particularly in higher eukaryotic genomes, has been an enormous challenge. Various experimental and computational approaches have been used to detect these sites; methods involving computational comparisons of related genomes have been particularly successful.

PMID:
14709165
[PubMed - indexed for MEDLINE]
PMCID:
PMC395725
Free PMC Article

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