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Semin Cancer Biol. 2003 Oct;13(5):379-85.

HLA-G and lymphoproliferative disorders.

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  • 1Laboratoire Universitaire d'Hématologie et de la Biologie des Cellules Sanguines, UPRES EA 22-33, Faculté de Médecine, Université de Rennes 1, Rennes, France. laurence.amiot@chu-rennes.fr


The immunomodulatory properties of the HLA-G molecule explain its relevance in malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and variable distribution of alternatively spliced HLA-G mRNA isoforms, (ii) a rare cell surface expression in diffuse large cell lymphomas with HLA class I loss in half of cases, and (iii) an increased serum level of sHLA-G in half of cases. The potential role of the microenvironment and/or tumoral process in HLA-G expression is discussed in the light of these data. HLA-G rather through its soluble isoform might provide a new way of immune evasion for lymphoid proliferations.

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