Nat Rev Mol Cell Biol. 2004 Jan;5(1):23-32.

The GGA proteins: adaptors on the move.

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Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T/Room 101, National Institutes of Health, Bethesda, Maryland 20892, USA. juan@helix.nih.gov

Abstract

The GGA proteins are a family of ubiquitously expressed, Arf-dependent clathrin adaptors that mediate the sorting of mannose-6-phosphate receptors between the trans-Golgi network and endosomes. Recent studies have elucidated the biochemical and structural bases for the interaction of the GGA proteins with many binding partners, and have shed light on the molecular and cellular mechanisms by which the GGA proteins participate in protein sorting.

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The GGA proteins: adaptors on the move.

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