Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S56-60.

Role of Ser/Thr kinases in the uncoupling of insulin signaling.

Author information

  • 1Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. yehiel.zick@weizmann.ac.il

Abstract

Insulin resistance refers to a decreased capacity of circulating insulin to regulate nutrient metabolism. It is associated with the development of type II diabetes, a 21st century epidemic. Recent studies reveal that agents that induce insulin resistance exploit phosphorylation-based negative feedback control mechanisms otherwise utilized by insulin itself, to uncouple the insulin receptor from its downstream effectors and thereby terminate insulin signal transduction. This article focuses on the cardinal role of Ser/Thr protein kinases, which phosphorylate insulin receptor substrates, as key players in the uncoupling of insulin signaling and the induction of an insulin resistance state.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk