Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6.

4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.

Ueda S, Terauchi H, Yano A, Ido M, Matsumoto M, Kawasaki M.

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Chemistry Research Laboratories, Dainippon Pharmaceutical Co., Ltd, Enoki-cho 33-94, Suita, 564-0053, Osaka, Japan. shigeo-ueda@dainippon-pharm.co.jp

Abstract

In our search for a novel class of inducible nitric oxide synthase (iNOS) inhibitors, 1,3-oxazolidin-2-imine was found to weakly inhibit iNOS. Further modifications of this compound resulted in a remarkable increase in both the in vivo and in vitro inhibitory activity and selectivity for iNOS.

PMID:: 14698148; [PubMed - indexed for MEDLINE]

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4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioa...
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.
Bioorg Med Chem Lett. 2004 Jan 19 ;14(2):313-6.

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