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Cancer Genet Cytogenet. 2004 Jan 1;148(1):80-4.

Establishment of cell lines from a primary hepatocellular carcinoma and its metastatis.

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  • 1Department of Clinical Oncology, The University of Hong Kong, Room 109, 1/F, School of Chinese Medicine Building, 10 Sassoon Road, Hong Kong, China.


Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world with a very poor prognosis that has been associated with tumor metastasis. The molecular mechanism of HCC metastasis is still unclear. In this study, we established cell lines from a primary tumor (H2-P) and its metastasis (H2-M). G-banding karyotyping, comparative genomic hybridization, and fluorescence in situ hybridization were applied to study these two cell lines and the results demonstrated that they are of the same origin. These cell lines provide a very useful tool to identify genetic alterations associated with HCC metastasis.

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