Leuk Lymphoma. 2003 Oct;44(10):1767-73.

Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.

Gallily R, Even-Chena T, Katzavian G, Lehmann D, Dagan A, Mechoulam R.

Source

The Lautenberg Center for General and Tumor Immunology, The Hebrew University Medical Faculty, Ein Kerem Campus, Jerusalem 1120, Israel. rgallily@md.huji.ac.il

Abstract

Two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabidiol-dimethylheptyl (CBD-DMH), induced apoptosis in a human acute myeloid leukemia (AML) HL-60 cell line. Apoptosis was determined by staining with bisBenzimide and propidium iodide. A dose dependent increase of apoptosis was noted, reaching 61 and 43% with 8 microg/ml CBD and 15 microg/ml CBD-DMH, respectively, after a 24 h treatment. Prior exposure of the cells to gamma-irradiation (800 cGy) markedly enhanced apoptosis, reaching values of 93 and 95%, respectively. Human monocytes from normal individuals were resistant to either cannabinoids or gamma-irradiation. Caspase-3 activation was observed after the cannabinoid treatment, and may represent a mechanism for the apoptosis. Our data suggest a possible new approach to treatment of AML.

PMID:: 14692532; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Related citations

Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression. [Mol Pharmacol. 2006]
Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.
McKallip RJ, Jia W, Schlomer J, Warren JW, Nagarkatti PS, Nagarkatti M. Mol Pharmacol. 2006 Sep; 70(3):897-908. Epub 2006 Jun 5.
The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. [Cell Mol Life Sci. 2006]
The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells.
Massi P, Vaccani A, Bianchessi S, Costa B, Macchi P, Parolaro D. Cell Mol Life Sci. 2006 Sep; 63(17):2057-66.
Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8. [Toxicol Appl Pharmacol. 2008]
Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8.
Wu HY, Chu RM, Wang CC, Lee CY, Lin SH, Jan TR. Toxicol Appl Pharmacol. 2008 Feb 1; 226(3):260-70. Epub 2007 Sep 20.
The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells. [Clin Cancer Res. 2003]
The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells.
Jung C, Motwani M, Kortmansky J, Sirotnak FM, She Y, Gonen M, Haimovitz-Friedman A, Schwartz GK. Clin Cancer Res. 2003 Dec 1; 9(16 Pt 1):6052-61.
Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation. [Neuro Oncol. 2002]
Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation.
Hussaini IM, Carpenter JE, Redpath GT, Sando JJ, Shaffrey ME, Vandenberg SR. Neuro Oncol. 2002 Jan; 4(1):9-21.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic ...
Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.
Leuk Lymphoma. 2003 Oct ;44(10):1767-73.

PubMed
HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor.
HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor.
Mol Cancer Ther. 2007 Jan ;6(1):173-83.

PubMed
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-co...
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.
Cancer Res. 2004 Mar 15 ;64(6):1943-50.

PubMed
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor o...
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
Biochem Pharmacol. 2010 Apr 1 ;79(7):955-66. Epub 2009 Nov 13 .

PubMed
Cannabinoid receptors in human astroglial tumors.
Cannabinoid receptors in human astroglial tumors.
J Neurochem. 2006 Aug ;98(3):886-93.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information