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Nat Immunol. 2004 Jan;5(1):64-73. Epub 2003 Dec 21.

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells.

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  • 1Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA. geber@adarc.org

Abstract

Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.

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PMID:
14691482
[PubMed - indexed for MEDLINE]
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