Your browser version may not work well with NCBI's Web applications. More information here...
1: Clin Invest Med. 2003 Dec;26(6):303-14.Links

Inflammatory bowel disease: Crohn's disease and the success of NODern genetics.

Newman B, Siminovitch K.

Genomic Medicine Division, University Health Network and the Department of Medicine, University of Toronto and Mount Sinai Hospital, Toronto, Ont.

The inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, are multifactorial in etiology, but a major causative role for genetic factors has long been recognized. Recent advances in genetic technologies have made dissection of the genes underlying common diseases possible; consequently, there is an emerging understanding of the inherited factors that predispose to IBD. In this review, we summarize current information on the genetics of IBD, emphasizing the discovery of CARD15 variants as susceptibility alleles for Crohn's disease and the impact of this discovery on patient care and in delineating pathogenesis of this complex disease.

PMID: 14690304 [PubMed - indexed for MEDLINE]