Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Am Geriatr Soc. 2004 Jan;52(1):86-92.

Efficacy, safety, and tolerability of sertraline in patients with late-life depression and comorbid medical illness.

Author information

  • 1Stanford University School of Medicine, Stanford, California Veterans Affairs Palo Alto Health Care System, Menlo Park, California 94305, USA. sheikh@stanford.edu

Erratum in

  • J Am Geriatr Soc. 2004 Jul;52(7):1228.

Abstract

OBJECTIVES:

To report on the efficacy, safety, and tolerability of sertraline in the treatment of elderly depres-sed patients with and without comorbid medical illness.

SETTING:

Multicenter.

DESIGN:

Randomized, double-blind, placebo-controlled study.

PARTICIPANTS:

A total of 752 patients aged 60 and older with diagnosis of major depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis.

MEASUREMENTS:

Outcome measures included the 17-item Hamilton Depression Scale (HAMD); the Clinical Global Depression-Severity/Improvement (CGI-S/CGI-I); efficacy and safety/adverse event assessments; Quality of Life, Enjoyment, and Satisfaction Questionnaire; and the Medical Outcomes Study 36-Item Short-Form Health Status Survey.

RESULTS:

In the overall sample, sertraline was superior to placebo on all three primary outcome measures, HAMD, and overall clinical severity and change (CGI-S/CGI-I). Furthermore, therapeutic response to sertraline was comparable in those with or without medical comorbidity, and there were no treatment-by-comorbidity group interactions. Sertraline was also associated with a faster time to response than placebo in the comorbid group (P<.006). Sertraline-treated patients in the comorbid group had similar adverse events and discontinuations when compared to those in the noncomorbid group.

CONCLUSION:

Sertraline was efficacious in reducing depressive symptomatology, regardless of the presence of comorbid medical illness. Sertraline was safe and well tolerated by patients with or without medical illness.

PMID:
14687320
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk