Format

Send to

Choose Destination
See comment in PubMed Commons below
Caries Res. 2004 Jan-Feb;38(1):9-14.

The effects of egg-derived antibodies to glucosyltransferases on dental caries in rats.

Author information

  • 1Center for Oral Biology, Karolinska Institutet at Novum and Division of Clinical Immunology, Karolinska Institutet at Huddinge Hospital, Huddinge, Sweden.

Abstract

The role of Streptococcus mutans in the development of dental caries is well recognized. Important virulence factors include the glucosyltransferases (gtf), essential for production of glucans. We evaluated the anticariogenic effects of orally administered chicken anti-cell-associated (CA) Gtf antibodies in desalivated rats. The animals were infected with S. mutans MT8148R and treated with chicken anti-CA-Gtf egg yolk antibodies (IgY) or nonimmune egg yolk powder. Smooth surface lesions were significantly lower in the anti-CA-Gtf-treated group in comparison to the control groups. Sulcal surface caries was also decreased and of less severity. Our study suggests that chicken anti-CA-Gtf antibodies may have promise as a prophylaxis for high caries risk patients.

Copyright 2004 S. Karger AG, Basel

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Write to the Help Desk