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Bioorg Med Chem Lett. 2004 Jan 5;14(1):267-70.

Structure-activity relationships of novel potent MurF inhibitors.

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  • 1Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, IL 60064, USA. yu-gui.y.gu@abbott.com

Abstract

A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC(50)=22 approximately 70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers.

PMID:
14684340
[PubMed - indexed for MEDLINE]
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