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Bioorg Med Chem Lett. 2004 Jan 5;14(1):235-8.

Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis.

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  • 1Chemical Sciences and Infectious Diseases, Wyeth Research, Pearl River, NY 10965, USA.

Abstract

Over 50 phenyl thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-positive bacteria including MRSA, VRE and PRSP. 3,4-Difluorophenyl 5-cyanothiazolylurea (3p) with clog P of 2.64 demonstrated antibacterial activity against both gram-positive and gram-negative bacteria.

PMID:
14684334
[PubMed - indexed for MEDLINE]
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