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British Biotech Pharmaceuticals Limited, Watlington Road, Oxford OX4 6LY, UK. stephen.east@evotecoai.com
A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3' amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections.
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