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    Bioorg Med Chem Lett. 2004 Jan 5;14(1):59-62.

    Peptide deformylase inhibitors with activity against respiratory tract pathogens.

    Source

    British Biotech Pharmaceuticals Limited, Watlington Road, Oxford OX4 6LY, UK. stephen.east@evotecoai.com

    Abstract

    A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3' amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections.

    PMID:
    14684298
    [PubMed - indexed for MEDLINE]

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