-
- Comment on:
-
Breast Cancer Res. 2004;6(1):R8-R17.
Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?
Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester, UK. Gareth.Evans@CMMC.nhs.uk
There has been contradictory evidence as to whether BRCA1 associated breast cancers have a poorer prognosis than non-BRCA1 cancers. In this issue of Breast Cancer Research Robson and colleagues provide further evidence for poorer survival in BRCA1 carriers and show that it could be attributed to failure to treat small node-negative grade 3 breast cancers with chemotherapy. There still remains little evidence for a survival difference for BRCA2 related breast cancers. Although the high contralateral breast cancer risk is confirmed by this study there is no real evidence for an increase in ipsilateral recurrence or new primary breast cancers in mutation carriers up to the 10-year point.
PMID: 14680492 [PubMed - indexed for MEDLINE]
PMCID: PMC314459
-
Cited by 2 PubMed Central articles
-
Prevalence and characteristics of pancreatic cancer in families with BRCA1 and BRCA2 mutations.
Kim DH, Crawford B, Ziegler J, Beattie MS.
Fam Cancer. 2009; 8(2):153-8. Epub 2008 Oct 15.
[Fam Cancer. 2009]
-
Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant.
de Bock GH, Schutte M, Krol-Warmerdam EM, Seynaeve C, Blom J, Brekelmans CT, Meijers-Heijboer H, van Asperen CJ, Cornelisse CJ, Devilee P, et al.
J Med Genet. 2004 Oct; 41(10):731-5.
[J Med Genet. 2004]