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Brain Res. 1992 Nov 20;596(1-2):315-9.

Repeated focal cerebral ischemia in gerbils is associated with development of infarction.

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  • 1Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.


We induced repeated focal cerebral ischemia in gerbils. Single 5-min ischemia produced neuronal damage limited to the ipsilateral CA1 and CA4 hippocampus. Two 5-min ischemic insults spaced at a 1-h interval caused selective neuronal damage to the CA1, CA3 and CA4 hippocampus, striatum, neocortex, and thalamus. Three 5-min ischemic insults at 1-h intervals produced infarction. Thus, repeated focal ischemia produced cumulative brain damage by conversion of sublethal damage into selective neuronal damage and of the neuronal damage into infarction.

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