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Br J Clin Pharmacol. 2004 Jan;57(1):6-14.

Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications.

Author information

  • 1Department of Health Care of the Elderly, Guy's, King's, and St Thomas' School of Medicine, King's College London, London. arduino.mangoni@kcl.ac.uk

Abstract

Advancing age is characterized by impairment in the function of the many regulatory processes that provide functional integration between cells and organs. Therefore, there may be a failure to maintain homeostasis under conditions of physiological stress. The reduced homeostatic ability affects different regulatory systems in different subjects, thus explaining at least partly the increased interindividual variability occurring as people get older. Important pharmacokinetic and pharmacodynamic changes occur with advancing age. Pharmacokinetic changes include a reduction in renal and hepatic clearance and an increase in volume of distribution of lipid soluble drugs (hence prolongation of elimination half-life) whereas pharmacodynamic changes involve altered (usually increased) sensitivity to several classes of drugs such as anticoagulants, cardiovascular and psychotropic drugs. This review focuses on the main age-related physiological changes affecting different organ systems and their implications for pharmacokinetics and pharmacodynamics of drugs.

PMID:
14678335
[PubMed - indexed for MEDLINE]
PMCID:
PMC1884408
Free PMC Article
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