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Biotechnol Lett. 2003 Nov;25(21):1843-6.

Microbial synthesis of (R)- and (S)-3,4-dimethoxyamphetamines through stereoselective transamination.

Author information

  • 1Life Science Research Laboratories, Life Science RD Center, Kaneka Corporation, 1-8, Miyamae-machi, Yakasago-cho, Takasago, Hyogo 676-8688, Japan. Akira_Iwasaki@kn.kaneka.co.jp

Abstract

Two soil isolates, Arthrobactersp. KNK168 and Pseudomonas sp. KNK425, aminated 3,4-dimethoxyphenylacetone in presence of sec-butylamine as an amino donor to yield 3,4-dimethoxyamphetamine (DMA) with different enantioselectivities. The former gave (R)-DMA (>99% e.e.) and the latter the (S)-isomer (>99% e.e.).

PMID:
14677709
[PubMed - indexed for MEDLINE]
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