Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Struct Biol. 2003 Dec;13(6):748-57.

The role of dynamics in allosteric regulation.

Author information

  • 1Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA. dkern@brandeis.edu

Abstract

The biomolecular conformational changes often associated with allostery are, by definition, dynamic processes. Recent publications have disclosed the role of pre-existing equilibria of conformational substates in this process. In addition, the role of dynamics as an entropic carrier of free energy of allostery has been investigated. Recent work thus shows that dynamics is pivotal to allostery, and that it constitutes much more than just the move from the 'T'-state to the 'R'-state. Emerging computational studies have described the actual pathways of allosteric change.

PMID:
14675554
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk