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Science. 2004 Jan 30;303(5658):644-9. Epub 2003 Dec 11.

Epigenetic dynamics of imprinted X inactivation during early mouse development.

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  • 1CNRS UMR218, Curie Institute, 26 rue d'Ulm, Paris 75005, France.

Abstract

The initiation of X-chromosome inactivation is thought to be tightly correlated with early differentiation events during mouse development. Here, we show that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation. A reversal of the inactive state, with a loss of epigenetic marks such as histone modifications and polycomb proteins, subsequently occurs in cells of the inner cell mass (ICM), which give rise to the embryo-proper in which random X inactivation is known to occur. This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo.

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PMID:
14671313
[PubMed - indexed for MEDLINE]
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