Adv Ther. 2003 Jul-Aug;20(4):177-90.

Use of topical metronidazole in moderate to severe rosacea.

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Department of Dermatology, UCLA School of Medicine, Santa Monica, California 90404, USA.

Abstract

Rosacea is a chronic condition requiring long-term therapy for control and maintenance. Numerous controlled studies have shown that metronidazole 0.75% in combination with oral antibiotics significantly reduces the number of papules and pustules and erythema severity scores in patients with severe disease. Topical metronidazole 0.75% also maintains long-term remissions after oral tetracycline has been discontinued. Although original studies involving topical metronidazole 0.75% used a twice-daily regimen, subsequent work has shown that this formulation used once daily is as effective as 1% metronidazole.

PMID:: 14669813; [PubMed - indexed for MEDLINE]

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Topical metronidazole maintains remissions of rosacea. [Arch Dermatol. 1998]
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Dahl MV, Katz HI, Krueger GG, Millikan LE, Odom RB, Parker F, Wolf JE Jr, Aly R, Bayles C, Reusser B, et al. Arch Dermatol. 1998 Jun; 134(6):679-83.
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Use of topical metronidazole in moderate to severe rosacea.
Use of topical metronidazole in moderate to severe rosacea.
Adv Ther. 2003 Jul-Aug ;20(4):177-90.

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