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Fertil Steril. 2003 Dec;80(6):1413-9.

Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection.

Author information

  • 1Male Fertility Laboratory, Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel. bartoob@mail.biu.ac.il

Abstract

OBJECTIVE:

To verify whether microinjection into retrieved oocytes of motile spermatozoa with morphologically normal nuclei, strictly defined by high power light microscopy (x >6000), improves the IVF/intracytoplasmic sperm injection (ICSI) pregnancy rate in couples with repeated ICSI failures.

DESIGN:

Comparative prospective study testing routine IVF/ICSI outcome parameters against those of modified ICSI based on morphological selection of spermatozoa with normal nuclei.

SETTING:

Male factor fertility laboratory and IVF center.

PATIENT(S):

Sixty-two couples, with at least two previous consequent pregnancy failed ICSI cycles, underwent a single ICSI trial preceded by morphological selection of spermatozoa with normal nuclei. Fifty of these couples were matched with couples who underwent a routine ICSI procedure at the same IVF center and exhibited the same number of previous ICSI failures.

INTERVENTION(S):

Standard ICSI and modified ICSI.

MAIN OUTCOME MEASURE(S):

ICSI pregnancy rate.

RESULT(S):

The matching study revealed that pregnancy rate after modified ICSI was significantly higher than that of the routine ICSI procedure (66.0% vs. 30.0%).

CONCLUSION(S):

Microinjection into retrieved oocytes of selected spermatozoa with strictly defined morphologically normal nuclei improves significantly the incidence of pregnancy in couples with previous ICSI failures.

PMID:
14667877
[PubMed - indexed for MEDLINE]
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