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Fertil Steril. 2003 Dec;80(6):1398-403.

Recombinant human follicle-stimulating hormone as a pretreatment for idiopathic oligoasthenoteratozoospermic patients undergoing intracytoplasmic sperm injection.

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  • 1Unità Operativa di Fisiopatologia della Riproduzione Umana, IRCCS S. de Bellis, Castellana Grotte, Ba, Italy. ecaroppo@tesseo.it

Abstract

OBJECTIVE:

To evaluate the efficacy of recombinant human FSH pretreatment in improving fertilization and pregnancy rates in oligozoospermic patients who are undergoing ICSI.

DESIGN:

Prospective, controlled, clinical study.

SETTING:

A research institute's reproductive unit.

PATIENT(S):

Thirty-three subjects with idiopathic oligoasthenoteratozoospermia who failed to conceive after previous ICSI attempts.

INTERVENTION(S):

Treatment with recombinant human FSH 150 IU for 3 months (23 patients) or no treatment (10 patients); clinical, hormonal, and seminal evaluation before and after treatment.

MAIN OUTCOME MEASURE(S):

Testicular volume, sperm parameters, FSH, LH, T, E(2), and inhibin B plasma levels, E/T ratio, and fertilization and pregnancy rates.

RESULT(S):

Treatment with 150 IU of FSH induced a significant increase in testicular volume and sperm parameters. The mean fertilization rate (FR) after ICSI cycles was higher, although not significantly, in treated patients when compared with controls (62.3 +/- 22.4 vs. 47.2 +/- 20.4). A strong negative correlation was observed between FR and serum FSH, inhibin B and E/T ratio in controls, whereas in treated patients, FR correlated with posttreatment inhibin B levels. The pregnancy rate in the entire treated group was 30.4%. No pregnancies were recorded in the control group.

CONCLUSION(S):

Recombinant human FSH may be a valuable pretreatment for oligozoospermic patients undergoing ICSI and may influence testicular paracrine activity.

PMID:
14667875
[PubMed - indexed for MEDLINE]
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