Mouth and dental examination is a systematic act in the etiologic follow up of an infectious endocarditis. Our study concerned 42 patients collected during 5 years period, starting july 1995 until July 2000, in the dental medical service of Hedi Chaker university hospital of Sfax oriented by the cardiovascular diseases service looking for a buccodental entry of bacteria. Our patients group is divided into 25 men and 17 women of 36.1 years mean age. Dental or parodontal lesions were observed in 25 patients. Panoramic X-rays showed periapical lesions of granuloma or cystic type in 15 patients. Among the etiological factors encountered we noticed dental acts accomplished without antibioprophylaxis and dental bacterial collection medically treated without extraction. Buccodental lesions were a frequent cause of the infectious endocarditis in 59.5% of the patients studied in this report, and were due more to defectious hygienic conditions than to a disabled dental act.