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    Ann Genet. 1992;35(3):157-60.

    Mapping of the Darier's disease gene by serogenetic markers: results in two large British kindreds.

    Source

    University Department of Dermatology, University of Newcastle upon Tyne, UK.

    Abstract

    The authors have carried out genetic linkage studies in 57 subjects from two large kindreds of Darier's disease, using a range of serological and biochemical polymorphisms of known chromosomal location. In these kindreds, about 7% of the genome has been excluded for close linkage to the Darier's disease gene. However, one family showed positive lod scores for linkage with the Duffy blood locus (1p13); lod scores were negative in the other family, but in the combined families the total score for this marker was still positive and does not completely exclude linkage.

    PMID:
    1466564
    [PubMed - indexed for MEDLINE]

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