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1: Neurosci Lett. 2003 Dec 26;353(3):157-60.Click here to read Links

Activation of c-fos expression in the rat inferior olivary nucleus by ghrelin.

Zhang W, Lin TR, Hu Y, Fan Y, Zhao L, Mulholland MW.

Department of Surgery, Michigan Gastrointestinal Peptide Center, University of Michigan, 2101 Taubman, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0346, USA.

Ghrelin, a novel 28-amino-acid hormone secreted by gastric oxyntic glands, stimulates food intake and induces adiposity. We examined whether ghrelin activates the inferior olivary nucleus. Systemic administration of ghrelin (37 nmol/kg) induced the expression of c-fos immunoreactivity in inferior olive neurons (n=6 rats). The number of neurons containing c-fos staining was significantly increased in the ghrelin-treated rats (65+/-14 vs.11+/-6 positive neurons, n=5). No significant difference in c-fos-positive neurons was observed between left (32+/-5) and right (33+/-6) inferior olivary nuclei. The number of c-fos-positive neurons in rats with bilateral vagotomy was not significantly different from those with intact vagal nerves. The present study demonstrates that ghrelin induces c-fos expression in inferior olivary nucleus via a central mechanism.

PMID: 14665405 [PubMed - indexed for MEDLINE]