The review presents the results of clinical-observations of side hepatotoxic effects of drugs from different pharmacological groups. Based on the data available in the literature, the authors systematized and supplemented the characteristic types of hepatic damages due to the use of drugs in different fields of medicine. The basic mechanisms responsible for the damaging effects of hepatotropic pharmacological agents are considered. The review places a particular emphasis on the major hepatic dysfunctions observed in oncological care when antitumor drugs having different mechanisms of action. This section of the review is supplemented with cases observed in the past years, wherein there are data on the hepatotoxicity of agents from the platin group, the nonsteroidal antiandrogen flutamide, topoisomerase II inhibitors in addition to the well-known alkylating drugs and antitumor antibiotics that have hepatotoxic properties.