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J Mol Biol. 2004 Jan 2;335(1):129-37.

Crystal structure of the catalytic domain of human ADAM33.

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  • 1Schering-Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.


Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.

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